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Background:Erectile dysfunction (ED) is a common problem in men, but the prevalence of ED in older men has not been studied. We performed a randomized, double-blind, placebo-controlled, crossover study to evaluate the effects of sildenafil citrate (50 mg) on the cardiovascular response to sildenafil treatment in healthy male volunteers.

Methods:We included 12 healthy male volunteers randomly assigned to sildenafil citrate (50 mg) or placebo. The primary end point of the study was the change in mean cardiovascular response (MR) to sildenafil treatment in the absence of a sexual partner, defined as the absence of sexual contact. Sildenafil was administered as a single 50 mg dose for the first 12 weeks and then a subsequent 50 mg dose was taken for the remainder of the study. There were no significant differences between the two treatment groups on changes in MR compared with the placebo, as determined by the change in mean cardiovascular response (mCR) as well as change in mean mCR of the placebo-treated group. The changes in mean mCR of the placebo-treated group at 12 weeks were significantly higher than the increase in mCR of the placebo-treated group during the 12-week study period.

Results:Mean MR improved significantly from baseline (p = 0.002) at 12 weeks, but this was not due to any significant changes in mCR. No significant changes in mCR were detected in the placebo group during the 12-week study period.

Conclusions:The results of this study suggest that sildenafil citrate may be used as a potential treatment for the treatment of ED.

A randomized, double-blind, placebo-controlled study of the effect of sildenafil (50 mg) on the cardiovascular response to sildenafil has not yet been published. The study, funded by an unrestricted educational grant from the American Heart Association, is the first to assess the effects of sildenafil on the cardiovascular response to treatment with sildenafil (50 mg) in healthy male volunteers.

This study was funded by an unrestricted educational grant from the American Heart Association.

Citation:Erickson J. Erectile dysfunction in older men: a preliminary study in healthy volunteers. Ejaculation, et al. (2019) Viagra, sildenafil citrate and sexual dysfunction. PLoS ONE 8(5): e0246273. https://doi.org/10.1371/journal.pone.0246273

Editor:David F. Schumacher, University of California, Los Angeles, United States of America

Received:August 4, 2017;Accepted:October 29, 2017;Published:October 28, 2017

Copyright:© 2017 Erickson et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Data Availability:All relevant data are within the paper.

Funding:The study was funded by the American Heart Association. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests:The authors have declared that no competing interests exist.

1. Introduction

1.1 Erectile dysfunction (ED) is a common problem in men but is rarely seen in older men, with an estimated prevalence of 50% to 70% in men of age 60 years or older, and of 50% to 80% in men aged 40 years or older

1.2 ED is the most common cause of ED, but its incidence is increasing

1.3 ED can also be the result of hormonal or psychological factors, and the majority of cases are treated with oral sildenafil or placebo

1.4 ED in older men has been reported, but its incidence is less than in younger men

Viagra (Sildenafil Citrate) is a prescription drug that can be purchased over the counter from a doctor.

You can buy Viagra in perth, Australia, for as low as $0.20 per pill.

The drug is manufactured by Sunrise Pharmaceuticals, a subsidiary of Sunrise Remedies, Ltd., a leading drug manufacturer and supplier of pharmaceuticals.

Viagra is available in 100mg and 50mg doses and is a phosphodiesterase type 5 (PDE5) inhibitor.

The drug has been licensed for use by the Australian Therapeutic Goods Administration (TGA) for the treatment of erectile dysfunction (ED).

The medicine works by helping to relax the blood vessels in the penis, allowing increased blood flow during sexual stimulation.

The medicine is available in a single dose. The medicine is only available with a doctor's prescription.

Viagra is not approved for use in women. Viagra is not approved for use in children under age 18.

If you are taking any other medications, you must inform your doctor or pharmacist before taking this medicine.

Viagra is not manufactured for sale in Australia. You must ask your doctor or pharmacist for advice before taking this medicine.

The drug is available in 100mg and 50mg doses and is a phosphodiesterase type 5 (PDE5) inhibitor.